RESUMO
Social media is bringing a new dimension to healthcare as it offers an environment through which the public, patients, and healthcare professionals can report health issues with the possibility of potentially improving health outcomes. Social networks are a powerful tool that ensures cooperation between users and is a mechanism of social interaction for a wide range of people. Although the use of social networks for communication in the field of health has a number of advantages, the exchange of information must be monitored for quality and reliability, as well as to preserve the confidentiality of users.
Assuntos
Comunicação , Rede Social , Humanos , Reprodutibilidade dos Testes , Instalações de Saúde , Pessoal de SaúdeRESUMO
The article presents data on sports, active forms of leisure, travel among elderly Russians. An important conclusion is made that health promotion by means of active recreation and sports among senior citizens in Russia is one of the directions of active longevity policy. An overview of charitable foundations for senior citizens of the Russian Federation and their activities in promoting an active lifestyle among elderly citizens is presented.
Assuntos
Estilo de Vida Saudável , Turismo , Humanos , Idoso , Promoção da Saúde , Estilo de Vida , Federação RussaRESUMO
Pulmonary haemorrhage is one of the most severe complications of pulmonary endarterectomy. To the most effective methods of combating this potentially fatal complication belongs extracorporeal membrane oxygenation (ECMO). In this article we describe a clinical case report regarding intraoperative use of central veno-arterial ECMO for pulmonary haemorrhage following thromboendarterectomy from the pulmonary arteries. According to the data of some authors, long-term ECMO support (for more than 4 days) may lead to such severe consequences as rethrombosis of pulmonary arteries and impairment of cerebral circulation. In our case we managed to avoid such complications, taking into consideration that the duration of ECMO amounted to 21 days. Resulting from the carried out comprehensive therapeutic measures by the time of discharge from hospital, a significant decrease in pulmonary artery pressure was achieved, with events of residual pulmonary hypertension.
Assuntos
Endarterectomia/efeitos adversos , Oxigenação por Membrana Extracorpórea , Hemorragia/cirurgia , Pneumopatias/cirurgia , Embolia Pulmonar/cirurgia , Hemorragia/etiologia , Humanos , Hipertensão Pulmonar/etiologia , Hipertensão Pulmonar/terapia , Pneumopatias/etiologiaRESUMO
Сhronic thromboembolic pulmonary hypertension (CTEPH) is a serious, under - diagnosed but potentially curable complication of pulmonary embolism (PE) due to medicine advancements. Lack of specific symptoms and signs makes its diagnosis challenging, requiring clinicians to be ready to suspect its presence in patients with dyspnea of unknown origin or persistent symptoms after the pulmonary embolism event. The success of the treatment of this disease depends entirely on early diagnosis. The complexity of the differential diagnosis is due to the problematic aspects including the lack of doctors' awareness of both the pathology itself and the possibilities of its modern treatment. Recently, in our country, the problem of the availability of expert centers with sufficient experience in providing highly specialized medical care to this rather difficult category of patients who need specific therapy has become very actual. The aim of this review is to provide contemporary information about epidemiology, pathophysiology, and clinical features of treating patients with CTEPH, and also, to increase awareness of potential PEâCTEPH transformation. In the article a 4-year - period of experience of the Meshalkin National Medical Research Center on management of CTEPH patients has been presented.
Assuntos
Hipertensão Pulmonar , Embolia Pulmonar , Doença Aguda , Doença Crônica , Endarterectomia , Humanos , Hipertensão Pulmonar/diagnóstico , Hipertensão Pulmonar/etiologia , Hipertensão Pulmonar/terapia , Embolia Pulmonar/complicações , Embolia Pulmonar/diagnóstico , Embolia Pulmonar/terapia , Fatores de RiscoRESUMO
OBJECTIVE: to assess the safety and efficiency of radiofrequency pulmonary artery ablation for treatment of residual pulmonary hypertension after pulmonary endarterectomy. MATERIAL AND METHODS: Radiofrequency pulmonary artery denervation (PADN) was performed in 16 patients (10 men, mean age 39 years [26; 51]). Indication for PADN was mean pulmonary artery pressure (PAP) >25 mm Hg with absence of proximal pulmonary artery lesion according to computer tomography. PADN procedure was performed with nonfluoroscopic 3D navigation system. RESULTS: After PADN mean PAP decreased from 37.3 mm Hg [29; 38] to 24.6 mm Hg [17; 30] (p=0.01); pulmonary vascular resistance decreased from 672 dyn·s·c -5 [387; 566] to 386 dyn·s·c -5 [155; 449] (Ñ=0.02); cardiac output increased from 3.4 l / min [3.2; 3.4] to 3.5 l / min [3.2; 4.0] (p=0.4); 6minute walk test distance increased from 427 meters [352; 510] to 447 meters [370; 525] (p=0.16), respectively. CONCLUSION: Initial results allow to assume that radiofrequency pulmonary artery denervation combined with optimal medical therapy may take its rightful place in the treatment of this category of patients.
Assuntos
Ablação por Cateter , Hipertensão Pulmonar , Adulto , Endarterectomia , Feminino , Humanos , Hipertensão Pulmonar/cirurgia , Masculino , Artéria Pulmonar , Resultado do Tratamento , Resistência VascularAssuntos
Hipertensão Pulmonar/cirurgia , Artéria Pulmonar/cirurgia , Embolia Pulmonar/complicações , Trombectomia , Humanos , Hipertensão Pulmonar/etiologia , Hipertensão Pulmonar/fisiopatologia , Avaliação de Resultados em Cuidados de Saúde , Trombectomia/efeitos adversos , Trombectomia/métodos , Trombectomia/estatística & dados numéricosRESUMO
Tris(2-hydroxyethyl)ammoniates of ezo-substituted aroxyalkane-carboxylic acids were examined for their effects on in vitro platelet aggregation under the influence of biogenic amines, as well as in lipid peroxidation. Hemocoagulation was evaluated in vivo. The agents tested were demonstrated no be a promising class of platelet aggregation inhibitors. They possess antioxidative effects, by reducing the level of malonic dialdehyde in induced hyperaggregation and the rate of lipid peroxidation. When given to animals, the agents decreased the activity of prothrombin factors.
Assuntos
Acetatos/farmacologia , Antioxidantes/farmacologia , Inibidores da Agregação Plaquetária/farmacologia , Agregação Plaquetária/efeitos dos fármacos , Difosfato de Adenosina/farmacologia , Animais , Peroxidação de Lipídeos/efeitos dos fármacos , Medições Luminescentes , Malondialdeído/sangue , Coelhos , Relação Estrutura-Atividade , Fatores de TempoAssuntos
Anti-Inflamatórios/uso terapêutico , Estomatite/tratamento farmacológico , Doença Aguda , Anti-Inflamatórios/efeitos adversos , Anti-Inflamatórios/farmacologia , Doença Crônica , Desoxirribonucleases/farmacologia , Desoxirribonucleases/uso terapêutico , Humanos , Peptídeo Hidrolases/efeitos adversos , Peptídeo Hidrolases/farmacologia , Peptídeo Hidrolases/uso terapêutico , Extratos Vegetais/efeitos adversos , Extratos Vegetais/farmacologia , Extratos Vegetais/uso terapêutico , Ribonucleases/farmacologia , Ribonucleases/uso terapêutico , Fatores de TempoRESUMO
Experimental and clinical study of the analgesic effects of mebicar and benzodiazepine series tranquilizers (sibazon and chlozepid) and their combinations with non-narcotic analgesics (amidopyrin, pyranal) or local anesthetic lidocaine has demonstrated a more marked effect of benzodiazepine derivatives on pain sensitivity thresholds as against mebicar. Tranquilizer combinations with other analgesics helped define the optimal premedication variants: benzodiazepine derivative augment analgesic activity whereas mebicar potentiates lidocaine effect.
Assuntos
Tranquilizantes/uso terapêutico , Adolescente , Adulto , Analgésicos/uso terapêutico , Animais , Relação Dose-Resposta a Droga , Avaliação de Medicamentos , Avaliação Pré-Clínica de Medicamentos , Quimioterapia Combinada , Feminino , Humanos , Lidocaína/uso terapêutico , Masculino , Pessoa de Meia-Idade , Dor/tratamento farmacológico , Coelhos , Ratos , Limiar Sensorial/efeitos dos fármacos , Odontalgia/tratamento farmacológicoRESUMO
Humoral immunity initially affected in patients with osteoarthrosis returns to normal under the influence of a multiple-modality treatment involving application of sulphide moor in combination with sodium chloride baths.
Assuntos
Banhos/métodos , Peloterapia/métodos , Osteoartrite/terapia , Cloreto de Sódio/uso terapêutico , Sulfetos/uso terapêutico , Adulto , Anticorpos Heterófilos/análise , Formação de Anticorpos , Doença Crônica , Feminino , Humanos , Imunoglobulinas/análise , Masculino , Pessoa de Meia-Idade , Osteoartrite/imunologiaAssuntos
Bloqueadores dos Canais de Cálcio/farmacologia , Agregação Plaquetária/efeitos dos fármacos , Animais , Plaquetas/efeitos dos fármacos , Plaquetas/metabolismo , Cálcio/sangue , Calmodulina/antagonistas & inibidores , AMP Cíclico/sangue , Depressão Química , Humanos , Fator de Ativação de Plaquetas/antagonistas & inibidoresRESUMO
It was shown in experiments on rabbits that dimethoxyphosphates of rare-earth elements injected intravenously displayed a marked anticoagulant activity. The highest effect was produced by compounds of neodymium, holmium, terbium, europium, thulium, dysprosium, and erbium.
Assuntos
Anticoagulantes/farmacologia , Metais Terras Raras/farmacologia , Fosfatos/farmacologia , Animais , Coagulação Sanguínea/efeitos dos fármacos , Coelhos , Tromboelastografia , Fatores de TempoAssuntos
Inibidores de Ciclo-Oxigenase , Complexos Multienzimáticos/antagonistas & inibidores , Oxirredutases/antagonistas & inibidores , Agregação Plaquetária/efeitos dos fármacos , Endoperóxidos de Prostaglandina/metabolismo , Prostaglandinas H/metabolismo , Tromboxano A2/biossíntese , Tromboxano-A Sintase/antagonistas & inibidores , Tromboxanos/biossíntese , Animais , Anticoagulantes/farmacologia , Ibuprofeno/farmacologia , Imidazóis/farmacologia , Técnicas In Vitro , CoelhosAssuntos
Artrite Reumatoide/imunologia , Banhos , Peloterapia , Cloreto de Sódio , Adulto , Artrite Reumatoide/terapia , Feminino , Humanos , Masculino , Pessoa de Meia-IdadeAssuntos
Músculos Abdominais/efeitos da radiação , Neoplasias Primárias Múltiplas/etiologia , Neoplasias Induzidas por Radiação/patologia , Sarcoma/etiologia , Feminino , Humanos , Pessoa de Meia-Idade , Neoplasias Primárias Múltiplas/patologia , Ovário/efeitos da radiação , Sarcoma/patologia , Neoplasias Uterinas/radioterapiaRESUMO
It was shown in experiments with three types of cells (dog red cells, hepatic cells of newborn Wistar rats, and culture of the renal epithelium of Vero monkeys) that cadmium in complexes with dimercaptoethanol penetrates the cells in an 8-33-fold greater amounts than free cations of metal. Unithiol increases cadmium penetration in the cells by 1.6-3 times only. The strength of cadmium binding with dimercaptopropranolol in the cells is greater than that with unithiol and free cations. Albumin limits penetration of free cations of cadmium and of complexes with dimercaptothiol to a greater degree than that of cadmium complexes with unithiols. The reasons for the differences revealed are discussed.